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Cardiac Findings in Fetal and Pediatric Autopsies: A 15-Year Retrospective Review.
Taweevisit, Mana; Thorner, Paul.
Affiliation
  • Taweevisit M; a Pathology, Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand.
  • Thorner P; a Pathology, Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand.
Fetal Pediatr Pathol ; 38(1): 14-29, 2019 Feb.
Article in En | MEDLINE | ID: mdl-30633599
ABSTRACT

INTRODUCTION:

Congenital heart defects (CHDs) carry significant morbidity and mortality in pediatric patients. This study determined the spectrum of CHDs based on fetal and pediatric autopsies.

METHODS:

Autopsy reports over a 15-year period were reviewed. Postmortem findings were correlated with echocardiography records.

RESULTS:

From 608 autopsies, 119 cases with CHDs were identified (11% of fetal, 53% of neonatal, 18% of infant, and 4.5% of childhood autopsies). Persistent left superior vena cava was the most common individual defect. 41% of cases had extracardiac malformations. 18.5% of cases had chromosomal abnormalities. Prenatal echocardiography was available in 52 cases, showing 85% correlation with autopsy findings. Defects missed by echocardiography were generally of mild severity.

CONCLUSION:

Postmortem examination is important to delineate the anatomy of CHDs, and recognize extracardiac malformations for identification of possible genetic syndromes. This information can be used for parental counseling and for assessment of accuracy of pre-mortem imaging studies.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Heart Defects, Congenital Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Language: En Journal: Fetal Pediatr Pathol Journal subject: PATOLOGIA / PEDIATRIA Year: 2019 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Heart Defects, Congenital Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Language: En Journal: Fetal Pediatr Pathol Journal subject: PATOLOGIA / PEDIATRIA Year: 2019 Document type: Article Affiliation country: