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Cyclodextrin Reduces Intravenous Toxicity of a Model Compound.
Mantik, Priscilla; Xie, Minli; Wong, Harvey; La, Hank; Steigerwalt, Ronald W; Devanaboyina, Uday; Ganem, Geoffrey; Shih, Danny; Flygare, John A; Fairbrother, Wayne J; Chakravarty, Paroma; Russell, David; Fernandez, Gilberto E; Narang, Ajit S.
Affiliation
  • Mantik P; Departments of Small Molecule Pharmaceutical Sciences, Genentech, Inc., One DNA Way, South San Francisco, California 94080. Electronic address: Mantik.Priscilla@Gene.com.
  • Xie M; Departments of Small Molecule Pharmaceutical Sciences, Genentech, Inc., One DNA Way, South San Francisco, California 94080.
  • Wong H; Drug Metabolism and Pharmacokinetics, Genentech, Inc., One DNA Way, South San Francisco, California 94080.
  • La H; Drug Metabolism and Pharmacokinetics, Genentech, Inc., One DNA Way, South San Francisco, California 94080.
  • Steigerwalt RW; Safety Assessment, Genentech, Inc., One DNA Way, South San Francisco, California 94080.
  • Devanaboyina U; Safety Assessment, Genentech, Inc., One DNA Way, South San Francisco, California 94080.
  • Ganem G; Safety Assessment, Genentech, Inc., One DNA Way, South San Francisco, California 94080.
  • Shih D; Safety Assessment, Genentech, Inc., One DNA Way, South San Francisco, California 94080.
  • Flygare JA; Discovery Chemistry, Genentech, Inc., One DNA Way, South San Francisco, California 94080.
  • Fairbrother WJ; Early Discovery Biochemistry, Genentech, Inc., One DNA Way, South San Francisco, California 94080.
  • Chakravarty P; Departments of Small Molecule Pharmaceutical Sciences, Genentech, Inc., One DNA Way, South San Francisco, California 94080.
  • Russell D; Departments of Small Molecule Pharmaceutical Sciences, Genentech, Inc., One DNA Way, South San Francisco, California 94080.
  • Fernandez GE; Departments of Small Molecule Pharmaceutical Sciences, Genentech, Inc., One DNA Way, South San Francisco, California 94080.
  • Narang AS; Departments of Small Molecule Pharmaceutical Sciences, Genentech, Inc., One DNA Way, South San Francisco, California 94080. Electronic address: Narang.Ajit@Gene.com.
J Pharm Sci ; 108(6): 1934-1943, 2019 06.
Article in En | MEDLINE | ID: mdl-30639736
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Cyclohexanes / Toxicity Tests, Acute / Drug Evaluation, Preclinical / Excipients / 2-Hydroxypropyl-beta-cyclodextrin Limits: Animals Language: En Journal: J Pharm Sci Year: 2019 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Cyclohexanes / Toxicity Tests, Acute / Drug Evaluation, Preclinical / Excipients / 2-Hydroxypropyl-beta-cyclodextrin Limits: Animals Language: En Journal: J Pharm Sci Year: 2019 Document type: Article