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Cbs overdosage is necessary and sufficient to induce cognitive phenotypes in mouse models of Down syndrome and interacts genetically with Dyrk1a.
Marechal, Damien; Brault, Véronique; Leon, Alice; Martin, Dehren; Lopes Pereira, Patricia; Loaëc, Nadege; Birling, Marie-Christine; Friocourt, Gaelle; Blondel, Marc; Herault, Yann.
Affiliation
  • Marechal D; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
  • Brault V; Centre National de la Recherche Scientifique, Illkirch, France.
  • Leon A; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.
  • Martin D; Université de Strasbourg, Illkirch, France.
  • Lopes Pereira P; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
  • Loaëc N; Centre National de la Recherche Scientifique, Illkirch, France.
  • Birling MC; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.
  • Friocourt G; Université de Strasbourg, Illkirch, France.
  • Blondel M; Inserm UMR 1078, Université de Bretagne Occidentale, Faculté de Médecine et des Sciences de la Santé, Etablissement Français du Sang (EFS) Bretagne, CHRU Brest, Hôpital Morvan, Laboratoire de Génétique Moléculaire, Brest, France.
  • Herault Y; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
Hum Mol Genet ; 28(9): 1561-1577, 2019 05 01.
Article in En | MEDLINE | ID: mdl-30649339
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenotype / Protein-Tyrosine Kinases / Protein Serine-Threonine Kinases / Down Syndrome / Gene Dosage / Cystathionine beta-Synthase / Epistasis, Genetic Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2019 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenotype / Protein-Tyrosine Kinases / Protein Serine-Threonine Kinases / Down Syndrome / Gene Dosage / Cystathionine beta-Synthase / Epistasis, Genetic Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2019 Document type: Article Affiliation country: