Immune context characterization and heterogeneity in primary tumors and pulmonary metastases from renal cell carcinoma.
Immunotherapy
; 11(1): 21-35, 2019 01.
Article
in En
| MEDLINE
| ID: mdl-30702014
ABSTRACT
AIM:
The knowledge of the immune context of renal cell carcinoma (RCC) is useful to predict benefit from immunotherapy. We retrospectively characterized the immune context of RCC patients underwent primary nephrectomy and pulmonary metastasectomy. MATERIALS &METHODS:
Intratumoral infiltrating lymphocytes and peritumoral renal infiltrating lymphocytes, lymphocyte subpopulations (CD4+, CD8+), PD-1, PD-L1 were explored in paired samples of primary RCC (T) and respective pulmonary metastases (M).RESULTS:
The immune variables demonstrated intralesional and intratumoral heterogeneity. Intralesional lymphocyte heterogeneity reached 76% of cases in T, 28% in M. The heterogeneity rate for PD-L1 expression was from 44% (T) to 56% (M); it correlated with better survival.CONCLUSION:
The immune context of RCC is highly variable both within a given tumor and among primary and metastases.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Renal Cell
/
CD4-Positive T-Lymphocytes
/
Lymphocytes, Tumor-Infiltrating
/
CD8-Positive T-Lymphocytes
/
Programmed Cell Death 1 Receptor
/
Kidney Neoplasms
/
Lung Neoplasms
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Immunotherapy
Journal subject:
ALERGIA E IMUNOLOGIA
/
TERAPEUTICA
Year:
2019
Document type:
Article
Affiliation country: