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Targeting Loxosceles spider Sphingomyelinase D with small-molecule inhibitors as a potential therapeutic approach for loxoscelism.
Lopes, Priscila Hess; Murakami, Mário T; Portaro, Fernanda C V; Mesquita Pasqualoto, Kerly Fernanda; van den Berg, Carmen; Tambourgi, Denise V.
Affiliation
  • Lopes PH; a Immunochemistry Laboratory , Butantan Institute , São Paulo , SP , Brazil.
  • Murakami MT; b Biosciences National Laboratory , National Centre for Research in Energy and Materials , Campinas , SP , Brazil.
  • Portaro FCV; a Immunochemistry Laboratory , Butantan Institute , São Paulo , SP , Brazil.
  • Mesquita Pasqualoto KF; c Alchemy - Innovation, Research & Development Ltda., Center of Innovation, Entrepreneurship and Technology (CIETEC) , University of São Paulo , SP , Brazil.
  • van den Berg C; d Centre for Medical Education , Cardiff University, School of Medicine , Cardiff , United Kingdom.
  • Tambourgi DV; a Immunochemistry Laboratory , Butantan Institute , São Paulo , SP , Brazil.
J Enzyme Inhib Med Chem ; 34(1): 310-321, 2019 Dec.
Article in En | MEDLINE | ID: mdl-30734604
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / Spider Bites / Skin Diseases / Phosphoric Diester Hydrolases / Small Molecule Libraries Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / Spider Bites / Skin Diseases / Phosphoric Diester Hydrolases / Small Molecule Libraries Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Document type: Article Affiliation country: Country of publication: