Exploration of the chondrosarcoma metabolome; the mTOR pathway as an important pro-survival pathway.

Addie, Ruben D; de Jong, Yvonne; Alberti, Gaia; Kruisselbrink, Alwine B; Que, Ivo; Baelde, Hans; Bovée, Judith V M G

Addie, Ruben D; de Jong, Yvonne; Alberti, Gaia; Kruisselbrink, Alwine B; Que, Ivo; Baelde, Hans; Bovée, Judith V M G.

Affiliation

Addie RD; Department of Pathology, Leiden University Medical Centre, Leiden, the Netherlands.
de Jong Y; Department of Pathology, Leiden University Medical Centre, Leiden, the Netherlands.
Alberti G; Department of Pathology, Leiden University Medical Centre, Leiden, the Netherlands.
Kruisselbrink AB; Department of Pathology, Leiden University Medical Centre, Leiden, the Netherlands.
Que I; Department of Radiology, Leiden University Medical Centre, Leiden, the Netherlands.
Baelde H; Department of Pathology, Leiden University Medical Centre, Leiden, the Netherlands.
Bovée JVMG; Department of Pathology, Leiden University Medical Centre, Leiden, the Netherlands.

J Bone Oncol ; 15: 100222, 2019 Apr.

Article in En | MEDLINE | ID: mdl-30766792

Key words

ACT, Atypical cartilaginous tumor; BLI, Bioluminescence imaging; BSA, Bovine serum albumin; BSO, Buthionine sulfoximine; Chondrosarcoma; D2HG, d-2-Hydroxyglutarate; DMSO, Dimethyl sulfoxide; ECAR, Extracellular acidification rate; FBS, Fetal bovine serum; FCCP, Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone; FLI, Fluorescence imaging; HIF, Hypoxia-inducible factor; IDH, Isocitrate dehydrogenase; Metabolism; OCR, Oxygen consumption rate; ROS, Reactive oxygen species; Rapamycin; mCT, Micro computed tomography; mTOR, Mammalian target of rapamycin; mTOR, Sapanisertib; α-KG, α-ketoglutarate

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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: J Bone Oncol Year: 2019 Document type: Article Affiliation country: Country of publication:

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