Protective effects of whey on rat liver damage induced by chronic alcohol intake.
Hum Exp Toxicol
; 38(6): 632-645, 2019 Jun.
Article
in En
| MEDLINE
| ID: mdl-30784321
ABSTRACT
In 2012, alcohol liver disease resulted in 3.3 million-5.9% of global deaths. This study introduced whey protection capacity against chronic alcohol-induced liver injury. Rats were orally administered to 12% ethanol solution in water (ad libitum, average 8.14 g of ethanol/kg body weight (b.w.)/day) alone or combined with whey ( per os, 2 g/kg b.w./day). After 6-week treatment, chronic ethanol consumption induced significant histopathological liver changes congestion, central vein dilation, hepatic portal vein branch dilation, Kupffer cells hyperplasia, fatty liver changes, and hepatocytes focal necrosis. Ethanol significantly increased liver catalase activity and glutathione reductase protein expression without significant effects on antioxidative enzymes glutathione peroxidase (GPx), copper-zinc-containing superoxide dismutase (CuZnSOD) and manganese-containing superoxide dismutase (MnSOD). Co-treatment with whey significantly attenuated pathohistological changes induced by ethanol ingestion and increased GSH-Px and nuclear factor kappa B (NF-κB) protein expression. Our results showed positive effects of whey on liver chronically exposed to ethanol, which seem to be associated with NF-κB-GPx signaling.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protective Agents
/
Chemical and Drug Induced Liver Injury, Chronic
/
Whey
/
Liver Diseases, Alcoholic
Limits:
Animals
Language:
En
Journal:
Hum Exp Toxicol
Journal subject:
TOXICOLOGIA
Year:
2019
Document type:
Article