Epithelial endoplasmic reticulum stress orchestrates a protective IgA response.
Science
; 363(6430): 993-998, 2019 03 01.
Article
in En
| MEDLINE
| ID: mdl-30819965
ABSTRACT
Immunoglobulin A (IgA) is the major secretory immunoglobulin isotype found at mucosal surfaces, where it regulates microbial commensalism and excludes luminal factors from contacting intestinal epithelial cells (IECs). IgA is induced by both T cell-dependent and -independent (TI) pathways. However, little is known about TI regulation. We report that IEC endoplasmic reticulum (ER) stress induces a polyreactive IgA response, which is protective against enteric inflammation. IEC ER stress causes TI and microbiota-independent expansion and activation of peritoneal B1b cells, which culminates in increased lamina propria and luminal IgA. Increased numbers of IgA-producing plasma cells were observed in healthy humans with defective autophagy, who are known to exhibit IEC ER stress. Upon ER stress, IECs communicate signals to the peritoneum that induce a barrier-protective TI IgA response.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunoglobulin A
/
Immunity, Mucosal
/
Epithelial Cells
/
Endoplasmic Reticulum Stress
/
Intestinal Mucosa
Limits:
Animals
/
Humans
Language:
En
Journal:
Science
Year:
2019
Document type:
Article
Affiliation country: