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Direct targeting of Gαq and Gα11 oncoproteins in cancer cells.
Annala, Suvi; Feng, Xiaodong; Shridhar, Naveen; Eryilmaz, Funda; Patt, Julian; Yang, JuHee; Pfeil, Eva M; Cervantes-Villagrana, Rodolfo Daniel; Inoue, Asuka; Häberlein, Felix; Slodczyk, Tanja; Reher, Raphael; Kehraus, Stefan; Monteleone, Stefania; Schrage, Ramona; Heycke, Nina; Rick, Ulrike; Engel, Sandra; Pfeifer, Alexander; Kolb, Peter; König, Gabriele; Bünemann, Moritz; Tüting, Thomas; Vázquez-Prado, José; Gutkind, J Silvio; Gaffal, Evelyn; Kostenis, Evi.
Affiliation
  • Annala S; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
  • Feng X; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.
  • Shridhar N; Laboratory for Experimental Dermatology, University Hospital Magdeburg, Leipziger Straße 44, 39120 Magdeburg, Germany.
  • Eryilmaz F; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
  • Patt J; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
  • Yang J; Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany.
  • Pfeil EM; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
  • Cervantes-Villagrana RD; Department of Pharmacology, Centro de Investigación y Estudios Avanzados del IPN (Cinvestav-IPN), Apartado Postal 14-740, CDMX 07360, Mexico.
  • Inoue A; Graduate School of Pharmaceutical Science, Tohoku University, Sendai 980-8578, Japan.
  • Häberlein F; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
  • Slodczyk T; Laboratory for Experimental Dermatology, University Hospital Magdeburg, Leipziger Straße 44, 39120 Magdeburg, Germany.
  • Reher R; Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
  • Kehraus S; Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
  • Monteleone S; Pharmaceutical Chemistry, Philipps-University Marburg, Marbacher Weg 6, 35032 Marburg, Germany.
  • Schrage R; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
  • Heycke N; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
  • Rick U; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
  • Engel S; Institute of Pharmacology and Clinical Pharmacy, University of Marburg, 35043 Marburg, Germany.
  • Pfeifer A; Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany.
  • Kolb P; Pharmaceutical Chemistry, Philipps-University Marburg, Marbacher Weg 6, 35032 Marburg, Germany.
  • König G; Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
  • Bünemann M; Institute of Pharmacology and Clinical Pharmacy, University of Marburg, 35043 Marburg, Germany.
  • Tüting T; Laboratory for Experimental Dermatology, University Hospital Magdeburg, Leipziger Straße 44, 39120 Magdeburg, Germany.
  • Vázquez-Prado J; Department of Pharmacology, Centro de Investigación y Estudios Avanzados del IPN (Cinvestav-IPN), Apartado Postal 14-740, CDMX 07360, Mexico.
  • Gutkind JS; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.
  • Gaffal E; Laboratory for Experimental Dermatology, University Hospital Magdeburg, Leipziger Straße 44, 39120 Magdeburg, Germany. evelyn.gaffal@med.ovgu.de kostenis@uni-bonn.de.
  • Kostenis E; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany. evelyn.gaffal@med.ovgu.de kostenis@uni-bonn.de.
Sci Signal ; 12(573)2019 03 19.
Article in En | MEDLINE | ID: mdl-30890659
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uveal Neoplasms / Drug Delivery Systems / GTP-Binding Protein alpha Subunits / GTP-Binding Protein alpha Subunits, Gq-G11 / Depsipeptides / Gain of Function Mutation / Melanoma / Neoplasm Proteins Limits: Animals / Humans Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2019 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uveal Neoplasms / Drug Delivery Systems / GTP-Binding Protein alpha Subunits / GTP-Binding Protein alpha Subunits, Gq-G11 / Depsipeptides / Gain of Function Mutation / Melanoma / Neoplasm Proteins Limits: Animals / Humans Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2019 Document type: Article Affiliation country: Country of publication: