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Structure-activity relationship studies of (E)-3,4-dihydroxystyryl alkyl sulfones as novel neuroprotective agents based on improved antioxidant, anti-inflammatory activities and BBB permeability.
Chen, Ying; Wu, Bolin; Hao, Yameng; Liu, Yunqi; Zhang, Zhili; Tian, Chao; Ning, Xianling; Guo, Ying; Liu, Junyi; Wang, Xiaowei.
Affiliation
  • Chen Y; Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
  • Wu B; Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
  • Hao Y; Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
  • Liu Y; Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
  • Zhang Z; Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
  • Tian C; Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
  • Ning X; Institute of Systems Biomedicine, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, 100191, China.
  • Guo Y; Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
  • Liu J; Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China. Electronic address: jyliu@bjmu.edu.cn.
  • Wang X; Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China. Electronic address: xiaoweiwang@bjmu.edu.cn.
Eur J Med Chem ; 171: 420-433, 2019 Jun 01.
Article in En | MEDLINE | ID: mdl-30928712
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood-Brain Barrier / Anti-Inflammatory Agents, Non-Steroidal / Neuroprotective Agents / Antioxidants Type of study: Prognostic_studies Limits: Animals Language: En Journal: Eur J Med Chem Year: 2019 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood-Brain Barrier / Anti-Inflammatory Agents, Non-Steroidal / Neuroprotective Agents / Antioxidants Type of study: Prognostic_studies Limits: Animals Language: En Journal: Eur J Med Chem Year: 2019 Document type: Article Affiliation country: Country of publication: