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Altered Domain Structure of the Prion Protein Caused by Cu2+ Binding and Functionally Relevant Mutations: Analysis by Cross-Linking, MS/MS, and NMR.
McDonald, Alex J; Leon, Deborah R; Markham, Kathleen A; Wu, Bei; Heckendorf, Christian F; Schilling, Kevin; Showalter, Hollis D; Andrews, Philip C; McComb, Mark E; Pushie, M Jake; Costello, Catherine E; Millhauser, Glenn L; Harris, David A.
Affiliation
  • McDonald AJ; Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.
  • Leon DR; Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA; Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA 02118, USA.
  • Markham KA; Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
  • Wu B; Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.
  • Heckendorf CF; Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA; Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA 02118, USA.
  • Schilling K; Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
  • Showalter HD; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
  • Andrews PC; Department of Biological Chemistry, Department of Chemistry, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
  • McComb ME; Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA; Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA 02118, USA.
  • Pushie MJ; Department of Surgery, Division of Neurosurgery, College of Medicine, University of Saskatchewan, Saskatoon, Canada.
  • Costello CE; Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA; Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA 02118, USA. Electronic address: cecmsms@bu.edu.
  • Millhauser GL; Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA. Electronic address: glennm@ucsc.edu.
  • Harris DA; Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA. Electronic address: daharris@bu.edu.
Structure ; 27(6): 907-922.e5, 2019 06 04.
Article in En | MEDLINE | ID: mdl-30956132
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Copper / Molecular Dynamics Simulation / Prion Proteins / Protein Domains / Mutation Limits: Animals / Humans Language: En Journal: Structure Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Year: 2019 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Copper / Molecular Dynamics Simulation / Prion Proteins / Protein Domains / Mutation Limits: Animals / Humans Language: En Journal: Structure Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Year: 2019 Document type: Article Affiliation country: Country of publication: