Coexisting Hodgkin's disease and mycosis fungoides. Immunohistochemical proof of its existence.
Arch Pathol Lab Med
; 110(11): 1029-34, 1986 Nov.
Article
in En
| MEDLINE
| ID: mdl-3096258
ABSTRACT
Hodgkin's disease and mycosis fungoides have been rarely reported in the same patient. This coexistence has been debated in the medical literature. We studied such a patient and report, to our knowledge, the first immunophenotypic evidence for such a coexistence. Reed-Sternberg cells and their variants stained with anti-Leu-M1, Hefi-1, anti-Tac, anti-HLA-DR, and OKT9, but were negative for T cell markers 3A1, Leu-1, Leu-2a, and Leu-3a, a phenotype typical of Hodgkin's disease; infiltrating small lymphocytes were predominantly T cells and were phenotypically normal. In the skin lesions, cells with the phenotype of Hodgkin's disease were not present; the infiltrate was composed of helper T lymphocytes that were 3A1-negative, a phenotype characteristic of the malignant cells of mycosis fungoides. Unexpectedly, a dermatopathic lymph node from the same patient showed the presence of the Leu-M1 antigen on the majority of normal-appearing interdigitating reticulum cells; this was not the case with control dermatopathic lymph nodes from patients without a malignancy. The significance, implications, and possible interrelationships of the findings are discussed.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hodgkin Disease
/
Mycosis Fungoides
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Arch Pathol Lab Med
Year:
1986
Document type:
Article