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Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity.
Tatsukawa, Tetsuya; Raveau, Matthieu; Ogiwara, Ikuo; Hattori, Satoko; Miyamoto, Hiroyuki; Mazaki, Emi; Itohara, Shigeyoshi; Miyakawa, Tsuyoshi; Montal, Mauricio; Yamakawa, Kazuhiro.
Affiliation
  • Tatsukawa T; 1Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama 351-0198 Japan.
  • Raveau M; 1Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama 351-0198 Japan.
  • Ogiwara I; 1Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama 351-0198 Japan.
  • Hattori S; 2Department of Physiology, Nippon Medical School, Bunkyo-ku, Tokyo, 113-8602 Japan.
  • Miyamoto H; 3Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake-shi, Aichi 470-1192 Japan.
  • Mazaki E; 1Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama 351-0198 Japan.
  • Itohara S; 1Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama 351-0198 Japan.
  • Miyakawa T; 4Laboratory for Behavioral Genetics, RIKEN Center for Brain Science, Wako, Saitama 351-0198 Japan.
  • Montal M; 5FIRST, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012 Japan.
  • Yamakawa K; 3Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake-shi, Aichi 470-1192 Japan.
Mol Autism ; 10: 15, 2019.
Article in En | MEDLINE | ID: mdl-30962870
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anxiety / Psychomotor Agitation / Social Behavior / NAV1.2 Voltage-Gated Sodium Channel / Autism Spectrum Disorder / Memory Aspects: Determinantes_sociais_saude Limits: Animals Language: En Journal: Mol Autism Year: 2019 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anxiety / Psychomotor Agitation / Social Behavior / NAV1.2 Voltage-Gated Sodium Channel / Autism Spectrum Disorder / Memory Aspects: Determinantes_sociais_saude Limits: Animals Language: En Journal: Mol Autism Year: 2019 Document type: Article