A Selective and Brain Penetrant p38&#945;MAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction.

Roy, Saktimayee M; Minasov, George; Arancio, Ottavio; Chico, Laura W; Van Eldik, Linda J; Anderson, Wayne F; Pelletier, Jeffrey C; Watterson, D Martin

A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction.

Roy, Saktimayee M; Minasov, George; Arancio, Ottavio; Chico, Laura W; Van Eldik, Linda J; Anderson, Wayne F; Pelletier, Jeffrey C; Watterson, D Martin.

Affiliation

Roy SM; Northwestern University , 320 East Superior Street , Chicago , Illinois 60611 , United States.
Minasov G; Northwestern University , 320 East Superior Street , Chicago , Illinois 60611 , United States.
Arancio O; Columbia University , New York , New York 10032 , United States.
Chico LW; Northwestern University , 320 East Superior Street , Chicago , Illinois 60611 , United States.
Van Eldik LJ; University of Kentucky , Lexington , Kentucky 40536 , United States.
Anderson WF; Northwestern University , 320 East Superior Street , Chicago , Illinois 60611 , United States.
Pelletier JC; Northwestern University , 320 East Superior Street , Chicago , Illinois 60611 , United States.
Watterson DM; Northwestern University , 320 East Superior Street , Chicago , Illinois 60611 , United States.

J Med Chem ; 62(11): 5298-5311, 2019 06 13.

Article in En | MEDLINE | ID: mdl-30978288

Subject(s)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / P38 Mitogen-Activated Protein Kinases / Protein Kinase Inhibitors / Cognitive Dysfunction / Nervous System Diseases Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2019 Document type: Article Affiliation country:

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