Bone mineral density in patients with longstanding type 1 diabetes: Results from the Canadian Study of Longevity in Type 1 Diabetes.
J Diabetes Complications
; 33(11): 107324, 2019 11.
Article
in En
| MEDLINE
| ID: mdl-31003922
ABSTRACT
AIM:
It is currently unclear if longstanding type 1 diabetes (T1D) affects bone mineral density (BMD).METHODS:
BMD measured by dual-energy X-ray absorptiometry and history of fragility fracture was determined in 75 T1D participants with ≥50â¯years of diabetes duration and 75 age- and sex-matched non-diabetic controls. BMD T-scores were determined for the lumbar spine (LS), total hip (TH) and femoral neck (FN).RESULTS:
T1D participants had median diabetes duration of 54 [52, 58] years, 41 (55%) were females, and mean A1c was 7.3⯱â¯0.8%. T1D females had higher LS T-scores compared to female controls (-0.3⯱â¯1.2 vs. -1.1⯱â¯1.4, pâ¯=â¯0.014), lower FN T-scores (-1.5⯱â¯1.0 vs. -1.2⯱â¯0.9, pâ¯=â¯0.042) and more fragility fractures (7 (17%) vs. 1 (2%), pâ¯=â¯0.021). In T1D, higher A1c was associated with higher adjusted odds of fragility fracture (pâ¯=â¯0.006). T1D males and controls showed no difference in BMD or fractures.CONCLUSIONS:
There were no substantial differences in T-score between T1D and matched controls; however, T1D females showed higher BMD at the LS and possibly paradoxically higher fragility fractures compared to matched controls. These findings suggest that lower T-scores may not be associated with a history of fragility fracture in females with longstanding T1D and that other factors should be investigated.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bone Density
/
Diabetes Mellitus, Type 1
/
Longevity
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
America do norte
Language:
En
Journal:
J Diabetes Complications
Journal subject:
ENDOCRINOLOGIA
Year:
2019
Document type:
Article
Affiliation country: