The Expression and Possible Functions of Tenascin-W During Development and Disease.
Front Cell Dev Biol
; 7: 53, 2019.
Article
in En
| MEDLINE
| ID: mdl-31032255
ABSTRACT
Tenascins are a family of multifunctional glycoproteins found in the extracellular matrix of chordates. Two of the tenascins, tenascin-C and tenascin-W, form hexabrachions. In this review, we describe the discovery and domain architecture of tenascin-W, its evolution and patterns of expression during embryogenesis and in tumors, and its effects on cells in culture. In avian and mammalian embryos tenascin-W is primarily expressed at sites of osteogenesis, and in the adult tenascin-W is abundant in certain stem cell niches. In primary cultures of osteoblasts tenascin-W promotes cell migration, the formation of mineralized foci and increases alkaline phosphatase activity. Tenascin-W is also prominent in many solid tumors, yet it is missing from the extracellular matrix of most adult tissues. This makes it a potential candidate for use as a marker of tumor stroma and a target for anti-cancer therapies.
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Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Front Cell Dev Biol
Year:
2019
Document type:
Article
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