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Optical Assessment of Spinal Cord Tissue Oxygenation Using a Miniaturized Near Infrared Spectroscopy Sensor.
Shadgan, Babak; Macnab, Andrew; Fong, Allan; Manouchehri, Neda; So, Kitty; Shortt, Katelyn; Streijger, Femke; Cripton, Peter A; Sayre, Eric C; Dumont, Guy A; Pagano, Roberto; Kim, Kyoung-Tae; Kwon, Brian K.
Affiliation
  • Shadgan B; Department of Orthopaedics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Macnab A; International Collaboration on Repair Discoveries (ICORD), Vancouver, British Columbia, Canada.
  • Fong A; Stellenbosch Institute for Advanced Study, Wallenberg Research Centre, Stellenbosch, South Africa.
  • Manouchehri N; International Collaboration on Repair Discoveries (ICORD), Vancouver, British Columbia, Canada.
  • So K; International Collaboration on Repair Discoveries (ICORD), Vancouver, British Columbia, Canada.
  • Shortt K; International Collaboration on Repair Discoveries (ICORD), Vancouver, British Columbia, Canada.
  • Streijger F; International Collaboration on Repair Discoveries (ICORD), Vancouver, British Columbia, Canada.
  • Cripton PA; International Collaboration on Repair Discoveries (ICORD), Vancouver, British Columbia, Canada.
  • Sayre EC; Department of Orthopaedics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Dumont GA; Orthopaedic and Injury Biomechanics Group, Departments of Mechanical Engineering and Orthopaedics and School of Biomedical Engineering, UBC, Vancouver, British Columbia, Canada.
  • Pagano R; Arthritis Research Canada, Richmond, British Columbia, Canada.
  • Kim KT; Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, British Columbia, Canada.
  • Kwon BK; Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, British Columbia, Canada.
J Neurotrauma ; 36(21): 3034-3043, 2019 11 01.
Article in En | MEDLINE | ID: mdl-31044642
ABSTRACT
Despite advances in the treatment of acute spinal cord injury (SCI), measures to mitigate permanent neurological deficits in affected patients are limited. Immediate post-trauma hemodynamic management of patients, to maintain blood supply and improve oxygenation to the injured spinal cord, is currently one aspect of critical care which clinicians can utilize to improve neurological outcomes. However, without a way to monitor the response of spinal cord hemodynamics and oxygenation in real time, optimizing hemodynamic management is challenging and limited in scope. This study aims to investigate the feasibility and validity of using a miniaturized multi-wavelength near-infrared spectroscopy (NIRS) sensor for direct transdural monitoring of spinal cord oxygenation in an animal model of acute SCI. Nine Yorkshire pigs underwent a weight-drop T10 contusion-compression injury and received episodes of ventilatory hypoxia and alterations in mean arterial pressure (MAP). Spinal cord hemodynamics and oxygenation were monitored throughout by a non-invasive transdural NIRS sensor, as well as an invasive intraparenchymal sensor as a comparison. NIRS parameters of tissue oxygenation were highly correlated with intraparenchymal measures of tissue oxygenation. In particular, during periods of hypoxia and MAP alterations, changes of NIRS-derived spinal cord oxygenated hemoglobin and tissue oxygenation percentage corresponded well with the changes in spinal cord oxygen partial pressures measured by the intraparenchymal sensor. Our data confirm that during hypoxic episodes and as changes occur in the MAP, non-invasive NIRS can detect and measure real-time changes in spinal cord oxygenation with a high degree of sensitivity and specificity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord / Spinal Cord Injuries / Spectroscopy, Near-Infrared Limits: Animals Language: En Journal: J Neurotrauma Journal subject: NEUROLOGIA / TRAUMATOLOGIA Year: 2019 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord / Spinal Cord Injuries / Spectroscopy, Near-Infrared Limits: Animals Language: En Journal: J Neurotrauma Journal subject: NEUROLOGIA / TRAUMATOLOGIA Year: 2019 Document type: Article Affiliation country: