[Injury of small intestinal mucosa in rats induced by aspirin and clopidogrel and the protective effect of teprenone].
Zhonghua Nei Ke Za Zhi
; 58(5): 382-384, 2019 May 01.
Article
in Zh
| MEDLINE
| ID: mdl-31060148
ABSTRACT
The purpose of this study was to investigate the injury of aspirin and clopidogrel on small intestinal mucosa in rats and the protective effect of teprenone. The study found that aspirin and clopidogrel could cause intestinal mucosal injury in rats, which was even worse with dual drugs. The mechanism of mucosal injury included free radical injury induced by aspirin and decreased synthesis of vascular endothelial growth factor (VEGF) by clopidogrel. Teprenone may repair intestinal mucosa via boosting VEGF level.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aspirin
/
Diterpenes
/
Clopidogrel
/
Intestinal Mucosa
/
Anti-Ulcer Agents
Limits:
Animals
Language:
Zh
Journal:
Zhonghua Nei Ke Za Zhi
Year:
2019
Document type:
Article
Affiliation country: