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Multiple SCN5A variant enhancers modulate its cardiac gene expression and the QT interval.
Kapoor, Ashish; Lee, Dongwon; Zhu, Luke; Soliman, Elsayed Z; Grove, Megan L; Boerwinkle, Eric; Arking, Dan E; Chakravarti, Aravinda.
Affiliation
  • Kapoor A; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030; ashish.kapoor@uth.tmc.edu aravinda.chakravarti@nyulangone.org.
  • Lee D; Center for Human Genetics and Genomics, New York University School of Medicine, New York, NY 10016.
  • Zhu L; Center for Human Genetics and Genomics, New York University School of Medicine, New York, NY 10016.
  • Soliman EZ; Epidemiological Cardiology Research Center, Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27101.
  • Grove ML; Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030.
  • Boerwinkle E; Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030.
  • Arking DE; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
  • Chakravarti A; Center for Human Genetics and Genomics, New York University School of Medicine, New York, NY 10016; ashish.kapoor@uth.tmc.edu aravinda.chakravarti@nyulangone.org.
Proc Natl Acad Sci U S A ; 116(22): 10636-10645, 2019 05 28.
Article in En | MEDLINE | ID: mdl-31068470
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / NAV1.5 Voltage-Gated Sodium Channel / Heart / Myocardium Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2019 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / NAV1.5 Voltage-Gated Sodium Channel / Heart / Myocardium Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2019 Document type: Article Country of publication: