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Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus.
Dedrick, Rebekah M; Guerrero-Bustamante, Carlos A; Garlena, Rebecca A; Russell, Daniel A; Ford, Katrina; Harris, Kathryn; Gilmour, Kimberly C; Soothill, James; Jacobs-Sera, Deborah; Schooley, Robert T; Hatfull, Graham F; Spencer, Helen.
Affiliation
  • Dedrick RM; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
  • Guerrero-Bustamante CA; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
  • Garlena RA; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
  • Russell DA; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
  • Ford K; Great Ormond Street Hospital, London, UK.
  • Harris K; Great Ormond Street Hospital, London, UK.
  • Gilmour KC; Great Ormond Street Hospital, London, UK.
  • Soothill J; Great Ormond Street Hospital, London, UK.
  • Jacobs-Sera D; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
  • Schooley RT; Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
  • Hatfull GF; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA. gfh@pitt.edu.
  • Spencer H; Great Ormond Street Hospital, London, UK. helen.spencer@gosh.nhs.uk.
Nat Med ; 25(5): 730-733, 2019 05.
Article in En | MEDLINE | ID: mdl-31068712
ABSTRACT
A 15-year-old patient with cystic fibrosis with a disseminated Mycobacterium abscessus infection was treated with a three-phage cocktail following bilateral lung transplantation. Effective lytic phage derivatives that efficiently kill the infectious M. abscessus strain were developed by genome engineering and forward genetics. Intravenous phage treatment was well tolerated and associated with objective clinical improvement, including sternal wound closure, improved liver function, and substantial resolution of infected skin nodules.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phage Therapy / Mycobacterium abscessus / Mycobacterium Infections, Nontuberculous Limits: Adolescent / Female / Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2019 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phage Therapy / Mycobacterium abscessus / Mycobacterium Infections, Nontuberculous Limits: Adolescent / Female / Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2019 Document type: Article Affiliation country: