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Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism.
Fox, Nicholas G; Yu, Xiaodi; Feng, Xidong; Bailey, Henry J; Martelli, Alain; Nabhan, Joseph F; Strain-Damerell, Claire; Bulawa, Christine; Yue, Wyatt W; Han, Seungil.
Affiliation
  • Fox NG; Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
  • Yu X; Merck & Co, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA.
  • Feng X; Discovery Sciences, Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT, 06340, USA.
  • Bailey HJ; SMPS, Janssen Research and Development, 1400 McKean Rd, Spring House, PA, 19477, USA.
  • Martelli A; Discovery Sciences, Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT, 06340, USA.
  • Nabhan JF; Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
  • Strain-Damerell C; Rare Disease Research Unit, Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA, 02139, USA.
  • Bulawa C; Rare Disease Research Unit, Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA, 02139, USA.
  • Yue WW; Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
  • Han S; Rare Disease Research Unit, Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA, 02139, USA.
Nat Commun ; 10(1): 2210, 2019 05 17.
Article in En | MEDLINE | ID: mdl-31101807
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbon-Sulfur Lyases / Friedreich Ataxia / Iron-Binding Proteins / Iron-Sulfur Proteins / Mitochondria Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbon-Sulfur Lyases / Friedreich Ataxia / Iron-Binding Proteins / Iron-Sulfur Proteins / Mitochondria Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Document type: Article Affiliation country: Country of publication: