Mechanical forces rewire metabolism in the tumor niche.
Mol Cell Oncol
; 6(3): 1592945, 2019.
Article
in En
| MEDLINE
| ID: mdl-31131310
ABSTRACT
Tumor niche extracellular matrix stiffening and tumor cell metabolic reprogramming are two fundamental mediators of tumor progression. We recently elucidated a mechanistic interconnection between mechanotransduction and tumor metabolic rewiring in cancer. We demonstrated a stiffness-dependent amino acid crosstalk between stromal and cancer cells that fuels tumor progression and metastatic spreading.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Mol Cell Oncol
Year:
2019
Document type:
Article
Affiliation country: