Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice.

Kapelyukh, Y; Henderson, C J; Scheer, N; Rode, A; Wolf, C R

Kapelyukh, Y; Henderson, C J; Scheer, N; Rode, A; Wolf, C R.

Affiliation

Kapelyukh Y; Systems Medicine, School of Medicine, University of Dundee, Jacqui Wood Cancer Centre, Ninewells Hospital, Dundee, United Kingdom (Y.K., C.J.H., C.R.W.) and Taconic Biosciences Inc., Rensselaer, New York (N.S., A.R.).
Henderson CJ; Systems Medicine, School of Medicine, University of Dundee, Jacqui Wood Cancer Centre, Ninewells Hospital, Dundee, United Kingdom (Y.K., C.J.H., C.R.W.) and Taconic Biosciences Inc., Rensselaer, New York (N.S., A.R.).
Scheer N; Systems Medicine, School of Medicine, University of Dundee, Jacqui Wood Cancer Centre, Ninewells Hospital, Dundee, United Kingdom (Y.K., C.J.H., C.R.W.) and Taconic Biosciences Inc., Rensselaer, New York (N.S., A.R.).
Rode A; Systems Medicine, School of Medicine, University of Dundee, Jacqui Wood Cancer Centre, Ninewells Hospital, Dundee, United Kingdom (Y.K., C.J.H., C.R.W.) and Taconic Biosciences Inc., Rensselaer, New York (N.S., A.R.).
Wolf CR; Systems Medicine, School of Medicine, University of Dundee, Jacqui Wood Cancer Centre, Ninewells Hospital, Dundee, United Kingdom (Y.K., C.J.H., C.R.W.) and Taconic Biosciences Inc., Rensselaer, New York (N.S., A.R.) c.r.wolf@dundee.ac.uk.

Drug Metab Dispos ; 47(8): 907-918, 2019 08.

Article in En | MEDLINE | ID: mdl-31147315

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxazines / Cytochrome P-450 CYP1A1 / Cytochrome P-450 CYP1A2 / Drug Evaluation, Preclinical Type of study: Evaluation_studies / Prognostic_studies Limits: Animals Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2019 Document type: Article

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