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CSN5 inhibition triggers inflammatory signaling and Rho/ROCK-dependent loss of endothelial integrity.
Majolée, Jisca; Pronk, Manon C A; Jim, Kin K; van Bezu, Jan S M; van der Sar, Astrid M; Hordijk, Peter L; Kovacevic, Igor.
Affiliation
  • Majolée J; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Physiology, Amsterdam Cardiovascular Sciences, De Boelelaan 1117, 1081HZ, Amsterdam, The Netherlands.
  • Pronk MCA; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Physiology, Amsterdam Cardiovascular Sciences, De Boelelaan 1117, 1081HZ, Amsterdam, The Netherlands.
  • Jim KK; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Microbiology and Infection Control, Amsterdam Infection and Immunity Institute, De Boelelaan 1117, 1081HZ, Amsterdam, The Netherlands.
  • van Bezu JSM; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Physiology, Amsterdam Cardiovascular Sciences, De Boelelaan 1117, 1081HZ, Amsterdam, The Netherlands.
  • van der Sar AM; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Microbiology and Infection Control, Amsterdam Infection and Immunity Institute, De Boelelaan 1117, 1081HZ, Amsterdam, The Netherlands.
  • Hordijk PL; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Physiology, Amsterdam Cardiovascular Sciences, De Boelelaan 1117, 1081HZ, Amsterdam, The Netherlands.
  • Kovacevic I; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Physiology, Amsterdam Cardiovascular Sciences, De Boelelaan 1117, 1081HZ, Amsterdam, The Netherlands. i.kovacevic@vumc.nl.
Sci Rep ; 9(1): 8131, 2019 05 31.
Article in En | MEDLINE | ID: mdl-31148579
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Hydrolases / Endothelium, Vascular / RhoA GTP-Binding Protein / RhoB GTP-Binding Protein / Intracellular Signaling Peptides and Proteins / Rho-Associated Kinases / COP9 Signalosome Complex / Inflammation Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2019 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Hydrolases / Endothelium, Vascular / RhoA GTP-Binding Protein / RhoB GTP-Binding Protein / Intracellular Signaling Peptides and Proteins / Rho-Associated Kinases / COP9 Signalosome Complex / Inflammation Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2019 Document type: Article Affiliation country: Country of publication: