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Overexpression of Galectin-3 in Chronic Lymphocytic Leukemia Is Associated With 17p Deletion: A Short Report.
Michalová, Zuzana; Coma, Matús; Kicová, Miroslava; Gabzdilová, Juliana; Dedinská, Kinga; Guman, Tomás; Hájiková, Martina; Veselinyová, Dominika; Giertlova, Mária; Gál, Peter; Sarisský, Marek.
Affiliation
  • Michalová Z; Central Laboratory of Clinical Cytometry, Department of Pharmacology, Faculty of Medicine, P.J. Safarik University & Medirex, a.s., Kosice, Slovak Republic.
  • Coma M; Department of Pharmacology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovak Republic.
  • Kicová M; Department of Pharmacology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovak Republic.
  • Gabzdilová J; Department of Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Inc., Kosice, Slovak Republic.
  • Dedinská K; Central Laboratory of Clinical Cytometry, Department of Pharmacology, Faculty of Medicine, P.J. Safarik University & Medirex, a.s., Kosice, Slovak Republic.
  • Guman T; Department of Pharmacology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovak Republic.
  • Hájiková M; Department of Hematology and Oncohematology, Louis Pasteur University Hospital and Faculty of Medicine, P.J. Safarik University, Kosice, Slovak Republic.
  • Veselinyová D; Department of Hematology and Oncohematology, Louis Pasteur University Hospital and Faculty of Medicine, P.J. Safarik University, Kosice, Slovak Republic.
  • Giertlova M; Department of Hematology and Oncohematology, Louis Pasteur University Hospital and Faculty of Medicine, P.J. Safarik University, Kosice, Slovak Republic.
  • Gál P; Central Laboratory of Clinical Cytometry, Department of Pharmacology, Faculty of Medicine, P.J. Safarik University & Medirex, a.s., Kosice, Slovak Republic.
  • Sarisský M; Department of Pharmacology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovak Republic.
Anticancer Res ; 39(6): 2805-2810, 2019 Jun.
Article in En | MEDLINE | ID: mdl-31177117
ABSTRACT
BACKGROUND/

AIM:

Galectins belong to the family of galactose-binding proteins known to play an important role in the processes of cell proliferation, differentiation, migration and neoplastic progression. Herein, we studied the expression of galectin-3 (Gal-3) in chronic lymphocytic leukemia (CLL). MATERIALS AND

METHODS:

The expression of Gal-3 was analyzed by means of multiparametric flow cytometry in normal and pathological B-cells from peripheral blood and bone marrow samples of 67 patients with CLL.

RESULTS:

Pathological B-cells expressed significantly higher levels of cytoplasmic Gal-3 than normal B-cells. Moreover, overexpression of cytoplasmic Gal-3 was observed in the prognostically poorest subgroup of CLL patients, namely those with 17p deletion.

CONCLUSION:

Our results indicate a possible role of galectin-3 in CLL pathophysiology and its potential value as a prognostic marker and therapeutic target.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromosomes, Human, Pair 17 / Leukemia, Lymphocytic, Chronic, B-Cell / Up-Regulation / Chromosome Deletion / Galectin 3 Type of study: Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Anticancer Res Year: 2019 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromosomes, Human, Pair 17 / Leukemia, Lymphocytic, Chronic, B-Cell / Up-Regulation / Chromosome Deletion / Galectin 3 Type of study: Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Anticancer Res Year: 2019 Document type: Article