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Erythrocyte-derived vesicles for circulating tumor cell capture and specific tumor imaging.
Chen, Ming; Liu, Ao; Chen, Bei; Zhu, Dao-Ming; Xie, Wei; Deng, Fang-Fang; Ji, Li-Wei; Chen, Li-Ben; Huang, Hui-Ming; Fu, You-Rong; Liu, Wei; Wang, Fu-Bing.
Affiliation
  • Chen M; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China. wfb20042002@sina.com.
  • Liu A; Huazhong Agricultural University, College of Plant Science and Technology, Wuhan, China.
  • Chen B; Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan, Hubei 430072, China. wliu@whu.edu.cn.
  • Zhu DM; Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan, Hubei 430072, China. wliu@whu.edu.cn.
  • Xie W; Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan, Hubei 430072, China. wliu@whu.edu.cn.
  • Deng FF; Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan, Hubei 430072, China. wliu@whu.edu.cn.
  • Ji LW; Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan, Hubei 430072, China. wliu@whu.edu.cn.
  • Chen LB; Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan, Hubei 430072, China. wliu@whu.edu.cn.
  • Huang HM; Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan, Hubei 430072, China. wliu@whu.edu.cn.
  • Fu YR; Department of Blood Transfusion, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Liu W; Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan, Hubei 430072, China. wliu@whu.edu.cn.
  • Wang FB; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China. wfb20042002@sina.com.
Nanoscale ; 11(25): 12388-12396, 2019 Jul 07.
Article in En | MEDLINE | ID: mdl-31215952
The precise diagnosis of cancer remains a great challenge; therefore, it is our research interest to develop safe, tumor-specific reagents. In this study, we designed nanovesicles derived from erythrocyte membranes; the nanovesicles are capable of recognizing tumor cells for both circulating tumor cell (CTC) capture and tumor imaging. The tumor-targeting molecules folic acid (FA) and fluorescein Cy5 were modified on the nanovesicle surface. The developed nanovesicles exhibit excellent tumor targeting ability both in vitro and in vivo for CTC capture and in tumor imaging. Compared with traditional immunomagnetic beads, the proposed nanovesicles are capable of avoiding non-specific adsorption as a derivative of red blood cells. Combined with a non-invasive means of micromanipulation, the nanometer-sized vesicles show a high purity of CTC capture (over 90%). In vivo, the nanovesicles can also be employed for efficient tumor imaging without obvious toxicity and side effects. In brief, the nanovesicles prepared herein show potential clinical application for integrated diagnosis in vitro and in vivo.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbocyanines / Erythrocytes / Optical Imaging / Neoplastic Cells, Circulating / Neoplasms, Experimental Limits: Animals / Female / Humans Language: En Journal: Nanoscale Year: 2019 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbocyanines / Erythrocytes / Optical Imaging / Neoplastic Cells, Circulating / Neoplasms, Experimental Limits: Animals / Female / Humans Language: En Journal: Nanoscale Year: 2019 Document type: Article Affiliation country: Country of publication: