Proinsulin/insulin ratio as a predictor of insulin resistance in patients with diabetic nephropathy.
Diabetes Metab Syndr
; 13(3): 2057-2060, 2019.
Article
in En
| MEDLINE
| ID: mdl-31235136
ABSTRACT
Patients with Diabetic nephropathy (DN) have an increase in cardiovascular mortality, and since IR may be a contributing factor. Therefore, the aim of this study was to assess the role of pro insulin/insulin ratio as a predictor of insulin resistance in patients with diabetic nephropathy PATIENTS AND METHODS:
A Case-control study was conducted in a total of 50 patients who diagnosed with type 2 diabetes mellitus from July 2017 to March 2018. The patients were divided into 2 groups according to presence of diabetic nephropathy. Demographic and clinical data were collected.RESULTS:
There is a significant increase in serum pro insulin/insulin ratio in patients with diabetic nephropathy patients compared to patients without diabetic nephropathy An association was found between increase serum pro insulin/insulin ratio and increase predicting of insulin resistance. Cut-off value of serum pro insulin/insulin ratio ≥0.1145 with sensitivity and specificity of 92.3 and 60.3 respectively as a predictor for insulin resistanceCONCLUSION:
This study demonstrate a strong relationship between insulin resistance and CKD and this relationship was stronger in the presence of obesity. Pro insulin/insulin ratio was found to be a significant predictor for insulin resistance.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proinsulin
/
Insulin Resistance
/
Biomarkers
/
Glucose Intolerance
/
Diabetes Mellitus, Type 2
/
Diabetic Nephropathies
/
Insulin
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Diabetes Metab Syndr
Year:
2019
Document type:
Article
Affiliation country: