Biocompatible Materials; Contrast Media; Fluorescent Dyes; Gold; Metal Nanoparticles; Multimodal Imaging/methods; Optical Imaging/methods; Quantum Dots; Surface-Active Agents; Tomography, X-Ray Computed/methods; Animals; Astrocytes/drug effects; Astrocytes/metabolism; Autophagy; Benzothiazoles/chemical synthesis; Benzothiazoles/pharmacokinetics; Benzothiazoles/toxicity; Biocompatible Materials/chemical synthesis; Biocompatible Materials/pharmacokinetics; Biocompatible Materials/toxicity; Cells, Cultured; Contrast Media/toxicity; Fluorenes/pharmacokinetics; Fluorenes/toxicity; Fluorescence Resonance Energy Transfer; Fluorescent Dyes/chemical synthesis; Fluorescent Dyes/pharmacokinetics; Fluorescent Dyes/toxicity; Gold/pharmacokinetics; Gold/toxicity; Human Umbilical Vein Endothelial Cells; Humans; Infrared Rays; Male; Metal Nanoparticles/toxicity; Polyethylene Glycols/pharmacokinetics; Polyethylene Glycols/toxicity; Polymers/pharmacokinetics; Polymers/toxicity; Quantum Dots/chemistry; Quantum Dots/toxicity; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Solubility; Styrenes/chemical synthesis; Styrenes/pharmacokinetics; Styrenes/toxicity; Surface-Active Agents/chemical synthesis; Surface-Active Agents/pharmacokinetics; Surface-Active Agents/toxicity; Tissue Distribution