Acute lymphoblastic leukemia in an adolescent presenting with acute hepatic failure: A case report.
Mol Clin Oncol
; 11(2): 135-138, 2019 Aug.
Article
in En
| MEDLINE
| ID: mdl-31316772
ABSTRACT
This case report describes a case of an unusual initial presentation of acute lymphoblastic leukemia in a previously healthy 15-year-old boy. He initially presented with a 6-day history of tiredness, decreased oral intake, nausea, vomiting, and jaundice (yellow sclera and dark urine) with evidence of acute hepatic failure, presenting as an increase in alanine aminotransferase (ALT)/aspartate aminotransferase (AST)/total bilirubin and a decrease in prothrombin activity. A complete serological evaluation for liver disease was negative. The levels of serum AST and ALT declined following hepatoprotective treatment. Bone marrow biopsy was diagnostic, revealing 68.15% blasts with markers consistent with acute B-cell lymphoblastic leukemia. This case report emphasizes that acute hepatic failure may be the initial presentation of ALL in an adolescent.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Mol Clin Oncol
Year:
2019
Document type:
Article