Pharmacotherapy in Pediatric Hematopoietic Cell Transplantation.
Handb Exp Pharmacol
; 261: 471-489, 2020.
Article
in En
| MEDLINE
| ID: mdl-31375921
ABSTRACT
Hematopoietic cell transplantation (HCT) is a curative treatment option for both malignant and nonmalignant diseases. Success of the procedure mainly depends on disease control and treatment-related complications. Pharmacotherapy plays a major role in HCT and significantly impacts the outcomes. Main drug use within HCT includes conditioning, GvHD prophylaxis, and prevention/treatment of infections.Increasing evidence suggests individualized dosing in (pediatric) HCT may improve outcome. Dose individualization may result in a better predictable drug treatment in terms of safety and efficacy, including timely immune reconstitution after HCT and optimal tumor or disease control, which may result in improved survival chances.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hematopoietic Stem Cell Transplantation
/
Graft vs Host Disease
Type of study:
Prognostic_studies
Limits:
Child
/
Humans
Language:
En
Journal:
Handb Exp Pharmacol
Year:
2020
Document type:
Article
Affiliation country: