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Discovery of Conformationally Restricted Human Glutaminyl Cyclase Inhibitors as Potent Anti-Alzheimer's Agents by Structure-Based Design.
Hoang, Van-Hai; Ngo, Van T H; Cui, Minghua; Manh, Nguyen Van; Tran, Phuong-Thao; Ann, Jihyae; Ha, Hee-Jin; Kim, Hee; Choi, Kwanghyun; Kim, Young-Ho; Chang, Hyerim; Macalino, Stephani Joy Y; Lee, Jiyoun; Choi, Sun; Lee, Jeewoo.
Affiliation
  • Hoang VH; Laboratory of Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, College of Pharmacy , Seoul National University , Seoul 08826 , Republic of Korea.
  • Ngo VTH; Laboratory of Theoretical and Computational Biophysics & Faculty of Pharmacy , Ton Duc Thang University , Ho Chi Minh City 75307 , Vietnam.
  • Cui M; National Leading Research Laboratory of Molecular Modeling & Drug Design, College of Pharmacy and Graduate School of Pharmaceutical Sciences , Ewha Womans University , Seoul 03760 , Republic of Korea.
  • Manh NV; Laboratory of Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, College of Pharmacy , Seoul National University , Seoul 08826 , Republic of Korea.
  • Tran PT; Department of Pharmaceutical Chemistry , Hanoi University of Pharmacy , Hanoi 10000 , Vietnam.
  • Ann J; Laboratory of Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, College of Pharmacy , Seoul National University , Seoul 08826 , Republic of Korea.
  • Ha HJ; Medifron DBT , Sandanro 349 , Danwon-Gu, Ansan-City , Gyeonggi-Do 15426 , Republic of Korea.
  • Kim H; Medifron DBT , Sandanro 349 , Danwon-Gu, Ansan-City , Gyeonggi-Do 15426 , Republic of Korea.
  • Choi K; Medifron DBT , Sandanro 349 , Danwon-Gu, Ansan-City , Gyeonggi-Do 15426 , Republic of Korea.
  • Kim YH; Medifron DBT , Sandanro 349 , Danwon-Gu, Ansan-City , Gyeonggi-Do 15426 , Republic of Korea.
  • Chang H; National Leading Research Laboratory of Molecular Modeling & Drug Design, College of Pharmacy and Graduate School of Pharmaceutical Sciences , Ewha Womans University , Seoul 03760 , Republic of Korea.
  • Macalino SJY; National Leading Research Laboratory of Molecular Modeling & Drug Design, College of Pharmacy and Graduate School of Pharmaceutical Sciences , Ewha Womans University , Seoul 03760 , Republic of Korea.
  • Lee J; Department of Global Medical Science , Sungshin University , Seoul 01133 , Republic of Korea.
  • Choi S; National Leading Research Laboratory of Molecular Modeling & Drug Design, College of Pharmacy and Graduate School of Pharmaceutical Sciences , Ewha Womans University , Seoul 03760 , Republic of Korea.
  • Lee J; Laboratory of Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, College of Pharmacy , Seoul National University , Seoul 08826 , Republic of Korea.
J Med Chem ; 62(17): 8011-8027, 2019 09 12.
Article in En | MEDLINE | ID: mdl-31411468
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anti-Anxiety Agents / Aminoacyltransferases / Enzyme Inhibitors / Drug Discovery / Alzheimer Disease Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2019 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anti-Anxiety Agents / Aminoacyltransferases / Enzyme Inhibitors / Drug Discovery / Alzheimer Disease Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2019 Document type: Article Country of publication: