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Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models.
Shen, Sida; Hadley, Melissa; Ustinova, Kseniya; Pavlicek, Jiri; Knox, Tessa; Noonepalle, Satish; Tavares, Mauricio T; Zimprich, Chad A; Zhang, Guiping; Robers, Matthew B; Barinka, Cyril; Kozikowski, Alan P; Villagra, Alejandro.
Affiliation
  • Shen S; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy , University of Illinois at Chicago , Chicago , Illinois 60612 , United States.
  • Hadley M; Department of Biochemistry and Molecular Medicine , The George Washington University , Washington, District of Columbia 20052 , United States.
  • Ustinova K; Laboratory of Structural Biology , Institute of Biotechnology of the Czech Academy of Sciences , Prumyslova 595 , 252 50 Vestec , Czech Republic.
  • Pavlicek J; Department of Biochemistry, Faculty of Natural Science , Charles University , Albertov 6 , 128 43 Prague 2 , Czech Republic.
  • Knox T; Laboratory of Structural Biology , Institute of Biotechnology of the Czech Academy of Sciences , Prumyslova 595 , 252 50 Vestec , Czech Republic.
  • Noonepalle S; Department of Biochemistry and Molecular Medicine , The George Washington University , Washington, District of Columbia 20052 , United States.
  • Tavares MT; Department of Biochemistry and Molecular Medicine , The George Washington University , Washington, District of Columbia 20052 , United States.
  • Zimprich CA; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy , University of Illinois at Chicago , Chicago , Illinois 60612 , United States.
  • Zhang G; Promega Corporation , Madison , Wisconsin 53711 , United States.
  • Robers MB; Bontac Bio-Engineering (Shenzhen) Co., Ltd , Shenzhen , Guangdong 518102 , China.
  • Barinka C; Promega Corporation , Madison , Wisconsin 53711 , United States.
  • Kozikowski AP; Laboratory of Structural Biology , Institute of Biotechnology of the Czech Academy of Sciences , Prumyslova 595 , 252 50 Vestec , Czech Republic.
  • Villagra A; StarWise Therapeutics LLC, University Research Park, Inc. , Madison , Wisconsin 53719 , United States.
J Med Chem ; 62(18): 8557-8577, 2019 09 26.
Article in En | MEDLINE | ID: mdl-31414801
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histone Deacetylase Inhibitors / Histone Deacetylase 6 / Hydroxamic Acids / Isoxazoles / Melanoma Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2019 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histone Deacetylase Inhibitors / Histone Deacetylase 6 / Hydroxamic Acids / Isoxazoles / Melanoma Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2019 Document type: Article Affiliation country: Country of publication: