Hypogonadism in Pediatric Health: Adult Medicine Concepts Fail.
Trends Endocrinol Metab
; 30(12): 879-890, 2019 12.
Article
in En
| MEDLINE
| ID: mdl-31471249
ABSTRACT
The classical definition of hypogonadism, used in adult medicine, as gonadal failure resulting in deficient steroid and gamete production, and its classification into hypergonadotropic and hypogonadotropic refer to primary gonadal and hypothalamic-pituitary disorders respectively and may lead to under- or misdiagnosis in pediatrics. Indeed, in children with primary gonadal failure, gonadotropin levels may be within the reference range for age. Conversely, since gonadotropins and steroids are normally low during childhood, it may prove impossible to show the existence of a hypogonadotropic state before pubertal age. Anti-Müllerian hormone (AMH) and inhibin B arise as more adequate biomarkers to assess gonadal function and increase the possibility of making an earlier diagnosis of hypogonadism in children, which may positively impact on timely management.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genitalia
/
Hypogonadism
Limits:
Female
/
Humans
/
Male
/
Pregnancy
Language:
En
Journal:
Trends Endocrinol Metab
Journal subject:
ENDOCRINOLOGIA
/
METABOLISMO
Year:
2019
Document type:
Article
Affiliation country: