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The molecular origin and taxonomy of mucinous ovarian carcinoma.
Cheasley, Dane; Wakefield, Matthew J; Ryland, Georgina L; Allan, Prue E; Alsop, Kathryn; Amarasinghe, Kaushalya C; Ananda, Sumitra; Anglesio, Michael S; Au-Yeung, George; Böhm, Maret; Bowtell, David D L; Brand, Alison; Chenevix-Trench, Georgia; Christie, Michael; Chiew, Yoke-Eng; Churchman, Michael; DeFazio, Anna; Demeo, Renee; Dudley, Rhiannon; Fairweather, Nicole; Fedele, Clare G; Fereday, Sian; Fox, Stephen B; Gilks, C Blake; Gourley, Charlie; Hacker, Neville F; Hadley, Alison M; Hendley, Joy; Ho, Gwo-Yaw; Hughes, Siobhan; Hunstman, David G; Hunter, Sally M; Jobling, Tom W; Kalli, Kimberly R; Kaufmann, Scott H; Kennedy, Catherine J; Köbel, Martin; Le Page, Cecile; Li, Jason; Lupat, Richard; McNally, Orla M; McAlpine, Jessica N; Mes-Masson, Anne-Marie; Mileshkin, Linda; Provencher, Diane M; Pyman, Jan; Rahimi, Kurosh; Rowley, Simone M; Salazar, Carolina; Samimi, Goli.
Affiliation
  • Cheasley D; Peter MacCallum Cancer Centre, Melbourne, Australia.
  • Wakefield MJ; Walter and Eliza Hall Institute, Parkville, Australia.
  • Ryland GL; The University of Melbourne, Melbourne, Australia.
  • Allan PE; Peter MacCallum Cancer Centre, Melbourne, Australia.
  • Alsop K; Peter MacCallum Cancer Centre, Melbourne, Australia.
  • Amarasinghe KC; Peter MacCallum Cancer Centre, Melbourne, Australia.
  • Ananda S; The University of Melbourne, Melbourne, Australia.
  • Anglesio MS; Peter MacCallum Cancer Centre, Melbourne, Australia.
  • Au-Yeung G; Peter MacCallum Cancer Centre, Melbourne, Australia.
  • Böhm M; Western Health, St. Albans, Australia.
  • Bowtell DDL; University of British Columbia, Vancouver, Canada.
  • Brand A; Peter MacCallum Cancer Centre, Melbourne, Australia.
  • Chenevix-Trench G; The University of Melbourne, Melbourne, Australia.
  • Christie M; Kinghorn Cancer Centre and Garvan Institute of Medical Research, Darlinghurst, Australia.
  • Chiew YE; Peter MacCallum Cancer Centre, Melbourne, Australia.
  • Churchman M; The University of Melbourne, Melbourne, Australia.
  • DeFazio A; Westmead Hospital, University of Sydney, Sydney, Australia.
  • Demeo R; Queensland Institute of Medical Research, Brisbane, Australia.
  • Dudley R; The University of Melbourne, Melbourne, Australia.
  • Fairweather N; Royal Melbourne Hospital, Parkville, Australia.
  • Fedele CG; Westmead Hospital, University of Sydney, Sydney, Australia.
  • Fereday S; Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Edinburgh Centre, University of Edinburgh, Edinburgh, UK.
  • Fox SB; Westmead Hospital, University of Sydney, Sydney, Australia.
  • Gilks CB; Peter MacCallum Cancer Centre, Melbourne, Australia.
  • Gourley C; Hudson Institute of Medical Research, Clayton, Australia.
  • Hacker NF; Hudson Institute of Medical Research, Clayton, Australia.
  • Hadley AM; Peter MacCallum Cancer Centre, Melbourne, Australia.
  • Hendley J; The University of Melbourne, Melbourne, Australia.
  • Ho GY; Peter MacCallum Cancer Centre, Melbourne, Australia.
  • Hughes S; The University of Melbourne, Melbourne, Australia.
  • Hunstman DG; Peter MacCallum Cancer Centre, Melbourne, Australia.
  • Hunter SM; The University of Melbourne, Melbourne, Australia.
  • Jobling TW; University of British Columbia, Vancouver, Canada.
  • Kalli KR; Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Edinburgh Centre, University of Edinburgh, Edinburgh, UK.
  • Kaufmann SH; The University of New South Wales, Sydney, Australia.
  • Kennedy CJ; Royal Brisbane and Womens Hospital, Brisbane, Australia.
  • Köbel M; Peter MacCallum Cancer Centre, Melbourne, Australia.
  • Le Page C; Walter and Eliza Hall Institute, Parkville, Australia.
  • Li J; Peter MacCallum Cancer Centre, Melbourne, Australia.
  • Lupat R; University of British Columbia, Vancouver, Canada.
  • McNally OM; Peter MacCallum Cancer Centre, Melbourne, Australia.
  • McAlpine JN; Monash Medical Centre, Clayton, Australia.
  • Mes-Masson AM; Mayo Clinic, Rochester, MN, USA.
  • Mileshkin L; Mayo Clinic, Rochester, MN, USA.
  • Provencher DM; Westmead Hospital, University of Sydney, Sydney, Australia.
  • Pyman J; The University of Calgary, Calgary, Canada.
  • Rahimi K; CRCHUM, Montreal, Canada.
  • Rowley SM; Peter MacCallum Cancer Centre, Melbourne, Australia.
  • Salazar C; Peter MacCallum Cancer Centre, Melbourne, Australia.
  • Samimi G; The University of Melbourne, Melbourne, Australia.
Nat Commun ; 10(1): 3935, 2019 09 02.
Article in En | MEDLINE | ID: mdl-31477716
ABSTRACT
Mucinous ovarian carcinoma (MOC) is a unique subtype of ovarian cancer with an uncertain etiology, including whether it genuinely arises at the ovary or is metastatic disease from other organs. In addition, the molecular drivers of invasive progression, high-grade and metastatic disease are poorly defined. We perform genetic analysis of MOC across all histological grades, including benign and borderline mucinous ovarian tumors, and compare these to tumors from other potential extra-ovarian sites of origin. Here we show that MOC is distinct from tumors from other sites and supports a progressive model of evolution from borderline precursors to high-grade invasive MOC. Key drivers of progression identified are TP53 mutation and copy number aberrations, including a notable amplicon on 9p13. High copy number aberration burden is associated with worse prognosis in MOC. Our data conclusively demonstrate that MOC arise from benign and borderline precursors at the ovary and are not extra-ovarian metastases.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Adenocarcinoma, Mucinous / Gene Expression Profiling / Carcinoma, Ovarian Epithelial Type of study: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Adenocarcinoma, Mucinous / Gene Expression Profiling / Carcinoma, Ovarian Epithelial Type of study: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Document type: Article Affiliation country: