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A modular PROTAC design for target destruction using a degradation signal based on a single amino acid.
Shanmugasundaram, Karthigayan; Shao, Peng; Chen, Han; Campos, Bismarck; McHardy, Stanton F; Luo, Tuoping; Rao, Hai.
Affiliation
  • Shanmugasundaram K; Department of Molecular Medicine, University of Texas Health, San Antonio, Texas 78229.
  • Shao P; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
  • Chen H; Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education and Beijing National Laboratory for Molecular Science, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
  • Campos B; Center for Innovative Drug Discovery, University of Texas, San Antonio, Texas 78249.
  • McHardy SF; Center for Innovative Drug Discovery, University of Texas, San Antonio, Texas 78249.
  • Luo T; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
  • Rao H; Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education and Beijing National Laboratory for Molecular Science, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
J Biol Chem ; 294(41): 15172-15175, 2019 10 11.
Article in En | MEDLINE | ID: mdl-31511327
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Small Molecule Libraries / Proteolysis Limits: Humans Language: En Journal: J Biol Chem Year: 2019 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Small Molecule Libraries / Proteolysis Limits: Humans Language: En Journal: J Biol Chem Year: 2019 Document type: Article Country of publication: