Efficacy of aspirin, prednisone, and multivitamin triple therapy in treating unexplained recurrent spontaneous abortion: A cohort study.
Int J Gynaecol Obstet
; 148(1): 21-26, 2020 Jan.
Article
in En
| MEDLINE
| ID: mdl-31523810
ABSTRACT
OBJECTIVE:
To assess the efficacy of aspirin, prednisone, and multivitamin triple therapy in treating unexplained recurrent spontaneous abortion (URSA).METHODS:
Data were reviewed from women with early RSA attending a hospital in Beijing, China, 2013-2017. Those with no abnormal indices (e.g., endocrine, coagulation, immune, genetic) were diagnosed as having URSA, and received aspirin, prednisone, and multivitamin therapy (triple therapy group, n=106) or folic acid monotherapy (control group, n=65). Treatment efficacy was evaluated as the rate of successful treatment (12-week pregnancy with obvious embryo and embryonic heart, nuchal translucency thickness <0.25 cm, size consistent with gestational age, no early malformation).RESULTS:
Overall, 362 women had early RSA and 171 (47.2%) had URSA. The rate of successful pregnancy was similar between the triple therapy (89.6%) and control (92.3%) groups (P=0.343). The rate of successful treatment was higher in the triple therapy (86.3%) than in the control (53.3%) group (P<0.001). In multivariate logistic regression analysis, triple therapy was associated with higher odds of successful treatment, whereas the number of spontaneous pregnancy losses was associated with lower odds of successful treatment.CONCLUSION:
The triple therapy of aspirin, prednisone, and multivitamin was found to be a good treatment option for women with URSA.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vitamins
/
Prednisone
/
Aspirin
/
Abortion, Habitual
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Asia
Language:
En
Journal:
Int J Gynaecol Obstet
Year:
2020
Document type:
Article
Affiliation country: