Polyethylenimine-Based Nanogels for Biomedical Applications.
Macromol Biosci
; 19(11): e1900272, 2019 11.
Article
in En
| MEDLINE
| ID: mdl-31531955
ABSTRACT
Nanogels (NGs) are 3-dimensional (3D) networks composed of hydrophilic or amphiphilic polymer chains, allowing for effective and homogeneous encapsulation of drugs, genes, or imaging agents for biomedical applications. Polyethylenimine (PEI), possessing abundant positively charged amine groups, is an ideal platform for the development of NGs. A variety of effective PEI-based NGs have been designed and much effort has been devoted to study the relationship between the structure and function of the NGs. In particular, PEI-based NGs can be prepared either using PEI as the major NG component or using PEI as a crosslinker. This review reports the recent progresses in the design of PEI-based NGs for gene and drug delivery and for bioimaging applications with a target focus to tackle the diagnosis and therapy of cancer.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polyethyleneimine
/
Drug Carriers
/
Drug Delivery Systems
/
Gene Transfer Techniques
/
Nanogels
Type of study:
Diagnostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Macromol Biosci
Journal subject:
BIOQUIMICA
Year:
2019
Document type:
Article
Affiliation country: