The failure of a DNA prime/protein boost regime and CTLA-4 mediated targeting to improve the potency of a DNA vaccine encoding Fasciola hepatica phosphoglycerate kinase in sheep.

Wesolowska, Agnieszka; Basalaj, Katarzyna; Zawistowska-Deniziak, Anna; Januszkiewicz, Kamil; Kozak Ljunggren, Monika; Jedlina, Luiza; Wedrychowicz, Halina

Wesolowska, Agnieszka; Basalaj, Katarzyna; Zawistowska-Deniziak, Anna; Januszkiewicz, Kamil; Kozak Ljunggren, Monika; Jedlina, Luiza; Wedrychowicz, Halina.

Affiliation

Wesolowska A; Witold Stefanski Institute of Parasitology, Polish Academy of Sciences, Twarda 51/55, 00-818 Warsaw, Poland. Electronic address: a.wesolowska@twarda.pan.pl.
Basalaj K; Witold Stefanski Institute of Parasitology, Polish Academy of Sciences, Twarda 51/55, 00-818 Warsaw, Poland.
Zawistowska-Deniziak A; Witold Stefanski Institute of Parasitology, Polish Academy of Sciences, Twarda 51/55, 00-818 Warsaw, Poland.
Januszkiewicz K; Witold Stefanski Institute of Parasitology, Polish Academy of Sciences, Twarda 51/55, 00-818 Warsaw, Poland.
Kozak Ljunggren M; Witold Stefanski Institute of Parasitology, Polish Academy of Sciences, Twarda 51/55, 00-818 Warsaw, Poland.
Jedlina L; Witold Stefanski Institute of Parasitology, Polish Academy of Sciences, Twarda 51/55, 00-818 Warsaw, Poland.
Wedrychowicz H; Witold Stefanski Institute of Parasitology, Polish Academy of Sciences, Twarda 51/55, 00-818 Warsaw, Poland.

Vet Immunol Immunopathol ; 217: 109941, 2019 Nov.

Article in En | MEDLINE | ID: mdl-31550657

Subject(s)
Key words

CTLA-4 targeting; DNA vaccines; Fasciola hepatica; Ruminants; prime/boost regime

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphoglycerate Kinase / Vaccination / Vaccines, DNA / Fasciola hepatica / Fascioliasis / CTLA-4 Antigen Limits: Animals Language: En Journal: Vet Immunol Immunopathol Year: 2019 Document type: Article

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