Investigating the risk of breast cancer among women exposed to chemicals: a nested case-control study using improved exposure estimates.
Int Arch Occup Environ Health
; 93(2): 261-269, 2020 02.
Article
in En
| MEDLINE
| ID: mdl-31650237
ABSTRACT
PURPOSE:
The aim of this study was to examine if exposures to chemicals at the workplace were associated with an increased risk of postmenopausal breast cancer, using improved exposure estimates.METHODS:
The design is a case-control study, nested within a cohort of women from the Malmö Diet and Cancer Study. The study comprised 2400 women, 731 cases and 1669 matched controls, born 1923-1950 and living in Malmö, Sweden between 1991 and 1996. An occupational hygienist reclassified the probability for exposure given by a job-exposure matrix, using individual data on work tasks. First-time diagnoses of invasive breast cancer were identified through the Swedish Cancer Registry.RESULTS:
Women exposed to chemicals in their occupational environment had a statistically significantly increased risk (OR 1.59, 95% CI 1.11-2.29) of breast cancer, and the risk correlated positively with duration of exposure but not with exposure intensity. Women exposed to chlorinated hydrocarbon solvents for more than 10 years had a significant higher risk of breast cancer (OR 3.06, 95% CI 1.18-7.96) as well as women exposed to oil mist for more than 10 years (OR 3.08, 95% CI 1.12-8.49).CONCLUSIONS:
This study gives some support to the hypothesis that exposure to organic solvents as well as oil mist is associated with increased risk of breast cancer.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Solvents
/
Industrial Oils
/
Breast Neoplasms
/
Occupational Exposure
/
Hydrocarbons, Chlorinated
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Int Arch Occup Environ Health
Year:
2020
Document type:
Article
Affiliation country: