Decreased GABA-A Receptor Binding in Association With ß-Lactam Antibiotic Use.
Clin Nucl Med
; 44(12): 981-982, 2019 Dec.
Article
in En
| MEDLINE
| ID: mdl-31689281
ABSTRACT
ß-Lactam antibiotics are proconvulsive. In laboratory animals, this effect seems to be predominantly mediated through inhibition of GABA-A receptors, but it has not been demonstrated in humans in vivo. We report images of a [C]Ro15-4513 PET from a 40-year-old man who had completed a 1-week course of flucloxacillin before it. Relative to healthy controls, the participant had significantly lower mean gray matter binding. These novel data suggest that, in humans, the proconvulsive effect of ß-lactam antibiotics is mediated via either competition for the same benzodiazepine-binding site as [C]Ro15-4513 or downregulation of GABA-A receptor expression.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, GABA-A
/
Floxacillin
/
Anti-Bacterial Agents
Type of study:
Risk_factors_studies
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Clin Nucl Med
Year:
2019
Document type:
Article
Affiliation country: