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Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.
Camell, Christina D; Günther, Patrick; Lee, Aileen; Goldberg, Emily L; Spadaro, Olga; Youm, Yun-Hee; Bartke, Andrzej; Hubbard, Gene B; Ikeno, Yuji; Ruddle, Nancy H; Schultze, Joachim; Dixit, Vishwa Deep.
Affiliation
  • Camell CD; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.
  • Günther P; Genomics and Immunoregulation, LIMES-Institute, University of Bonn, 53115 Bonn, Germany; PRECISE Platform for Single Cell Genomics and Epigenomics at the University of Bonn and the German Center for Neurodegenerative Diseases, Bonn, Germany.
  • Lee A; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.
  • Goldberg EL; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.
  • Spadaro O; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.
  • Youm YH; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.
  • Bartke A; Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62702, USA.
  • Hubbard GB; Department of Pathology, Barshop Institute, UT Health San Antonio, San Antonio, TX 78229, USA.
  • Ikeno Y; Department of Pathology, Barshop Institute, UT Health San Antonio, San Antonio, TX 78229, USA; Geriatric Research Education and Clinical Center, Audie L. Murphy VA Hospital, South Texas Veterans Health Care System, San Antonio, TX 78229, USA.
  • Ruddle NH; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520, USA.
  • Schultze J; Genomics and Immunoregulation, LIMES-Institute, University of Bonn, 53115 Bonn, Germany; PRECISE Platform for Single Cell Genomics and Epigenomics at the University of Bonn and the German Center for Neurodegenerative Diseases, Bonn, Germany.
  • Dixit VD; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA; Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address: vishwa.dixit@yale.edu.
Cell Metab ; 30(6): 1024-1039.e6, 2019 12 03.
Article in En | MEDLINE | ID: mdl-31735593
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / B-Lymphocytes / Adipose Tissue / Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein / Homeostasis Limits: Animals Language: En Journal: Cell Metab Journal subject: METABOLISMO Year: 2019 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / B-Lymphocytes / Adipose Tissue / Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein / Homeostasis Limits: Animals Language: En Journal: Cell Metab Journal subject: METABOLISMO Year: 2019 Document type: Article Affiliation country: Country of publication: