Economic and Health Care Burdens of Hepatitis Delta: A Study of Commercially Insured Adults in the United States.
Hepatology
; 72(2): 399-411, 2020 08.
Article
in En
| MEDLINE
| ID: mdl-31804707
ABSTRACT
BACKGROUND AND AIMS:
The paucity of data regarding the extent of hepatitis delta virus (HDV) associated health care burden in the United States is an important obstacle to assessing the cost-effectiveness of potential intervention strategies. In this study, we characterized the health care use and cost burdens of HDV in the United States using real-world claims data. APPROACH ANDRESULTS:
We conducted a case-control study using the Truven Health MarketScan Commercial Claims databases from 2011-2014. A total of 2,727 HDV cases were matched 11 by sociodemographic characteristics and comorbidities to chronic hepatitis B virus (HBV) controls using propensity scores. The HDV group had significantly higher prevalence of substance abuse, sexually transmitted diseases, decompensated cirrhosis, cirrhosis, and hepatitis C virus compared to patients with chronic HBV. First HDV diagnosis was associated with significant increases in the total number of health care claims (25.61 vs. 28.99; P < 0.0001) and total annual health care costs ($19,476 vs. $23,605; P < 0.0001) compared with pre-HDV baseline. The case-control analysis similarly indicated higher total claims (28.99 vs. 25.19; P < 0.0001) and health care costs ($23,605 vs. $18,228; P < 0.0001) in HDV compared with HBV alone. Compared with HBV controls, HDV cases had an adjusted incident rate ratio of 1.16 (95% confidence interval 1.10, 1.22) times the total number of annual claims and an adjusted incident rate ratio 1.32 (95% confidence interval 1.17, 1.48) times the total annual health care cost.CONCLUSIONS:
HDV is associated with higher health care use and cost burden than HBV alone, underscoring the need for improved screening and treatment.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hepatitis D
/
Health Care Costs
/
Hepatitis B, Chronic
/
Insurance, Health
Type of study:
Health_economic_evaluation
/
Observational_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
America do norte
Language:
En
Journal:
Hepatology
Year:
2020
Document type:
Article