Current and potential treatments for primary biliary cholangitis.
Lancet Gastroenterol Hepatol
; 5(3): 306-315, 2020 03.
Article
in En
| MEDLINE
| ID: mdl-31806572
ABSTRACT
Up to 40% of patients with primary biliary cholangitis have an incomplete response to first-line treatment with ursodeoxycholic acid. Obeticholic acid was approved by the US Food and Drug Administration in 2016 as a second-line treatment for patients with primary biliary cholangitis who are unresponsive to ursodeoxycholic acid; however, approximately 50% of patients might need additional treatments to reach therapeutic goals. A considerable need exists for effective treatment options to prevent progression to liver transplantation or death in these patients. Drugs that might modulate immunological abnormalities in primary biliary cholangitis have been studied but their effectiveness varies. Budesonide, ciclosporin, and rituximab have shown potential in modifying the disease process. Bezafibrate, a pan-peroxisome proliferator-activated receptor agonist, has been shown to ameliorate deranged bile acid homoeostasis and attenuate raised concentrations of liver enzymes associated with primary biliary cholangitis. As the mechanisms underlying the pathogenesis and progression of primary biliary cholangitis are further clarified, specific targeted therapies are under development with promising early results. Various therapeutic target bile acid homeostasis, immune dysfunction, and fibrogenetic pathways are being studied. A better understanding of the biochemical and clinical effects of the therapies in development bear discussion, both to guide the discovery of new therapies and to inform clinicians so that rational treatment regimens can be tailored to patients once they become available.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Homeostasis
/
Liver Cirrhosis, Biliary
Type of study:
Observational_studies
/
Qualitative_research
/
Risk_factors_studies
Country/Region as subject:
America do norte
Language:
En
Journal:
Lancet Gastroenterol Hepatol
Year:
2020
Document type:
Article
Affiliation country: