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Burden of disease in pediatric narcolepsy: a claims-based analysis of health care utilization, costs, and comorbidities.
Carls, Ginger; Reddy, Sheila Reiss; Broder, Michael S; Tieu, Ryan; Villa, Kathleen F; Profant, Judi; Halbower, Ann C.
Affiliation
  • Carls G; Medical Affairs, Jazz Pharmaceuticals, Inc., 3170 Porter Dr, Palo Alto, CA 94304, USA. Electronic address: gingercarls@gmail.com.
  • Reddy SR; Partnership for Health Analytic Research, LLC, 280 South Beverly Dr, Beverly Hills, CA 90212, USA. Electronic address: srreddy@pharllc.com.
  • Broder MS; Partnership for Health Analytic Research, LLC, 280 South Beverly Dr, Beverly Hills, CA 90212, USA. Electronic address: mbroder@pharllc.com.
  • Tieu R; Partnership for Health Analytic Research, LLC, 280 South Beverly Dr, Beverly Hills, CA 90212, USA. Electronic address: ryanstieu@gmail.com.
  • Villa KF; Medical Affairs, Jazz Pharmaceuticals, Inc., 3170 Porter Dr, Palo Alto, CA 94304, USA. Electronic address: Kathleen.Villa@jazzpharma.com.
  • Profant J; Medical Affairs, Jazz Pharmaceuticals, Inc., 3170 Porter Dr, Palo Alto, CA 94304, USA. Electronic address: Judith.Profant@jazzpharma.com.
  • Halbower AC; University of Colorado School of Medicine, 13001 E 17th Pl, Aurora, CO 80045, USA. Electronic address: Ann.Halbower@childrenscolorado.org.
Sleep Med ; 66: 110-118, 2020 02.
Article in En | MEDLINE | ID: mdl-31841742
BACKGROUND: This study analyzed a privately insured pediatric population with and without narcolepsy to determine the impact of pediatric narcolepsy on comorbidities, health care utilization, and cost. Additional analyses compared narcolepsy type 1 and type 2. METHODS: This retrospective cross-sectional study identified US patients with narcolepsy <18 years of age with ≥2 claims with a diagnosis code of narcolepsy using Truven MarketScan® data 2011 to 2015. Patients were matched to controls without narcolepsy. Comorbid conditions, health care utilization, and costs were measured by calendar year. P values are nominal, and no adjustments for multiplicity or multiple comparisons were made. RESULTS: A total of 1427 pediatric patients with narcolepsy were identified and matched with 4281 controls from 2011 to 2015. Patients with narcolepsy had more comorbid conditions (mean 5.8 vs 2.4, nominal P < 0.001). Respiratory diseases and mood disorders were more common in patients with narcolepsy than controls (57% vs 32% and 56% vs 14%, respectively; both nominal P < 0.001). Compared to controls, patients with narcolepsy underwent more diagnostic tests (electroencephalogram, EEG [0.13 vs 0.0053]) and brain computed tomography, CT/magnetic resonance imaging, MRI (0.26 vs 0.022; both nominal P < 0.001). Mean annual inpatient days (0.71 vs 0.15), emergency department visits (0.51 vs 0.15), and outpatient office visits (8.6 vs 2.3) were higher for patients with narcolepsy than controls (all nominal P < 0.001). Annual mean health care costs were higher for patients with narcolepsy versus controls ($15,797 vs $2449, nominal P < 0.001). CONCLUSION: Pediatric patients with narcolepsy had greater comorbidity, higher health care utilization, and higher costs than patients without narcolepsy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pediatrics / Insurance Claim Review / Patient Acceptance of Health Care / Comorbidity / Health Care Costs / Cost of Illness / Narcolepsy Type of study: Health_economic_evaluation / Observational_studies / Prevalence_studies / Risk_factors_studies Aspects: Implementation_research Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Country/Region as subject: America do norte Language: En Journal: Sleep Med Journal subject: NEUROLOGIA / PSICOFISIOLOGIA Year: 2020 Document type: Article Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pediatrics / Insurance Claim Review / Patient Acceptance of Health Care / Comorbidity / Health Care Costs / Cost of Illness / Narcolepsy Type of study: Health_economic_evaluation / Observational_studies / Prevalence_studies / Risk_factors_studies Aspects: Implementation_research Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Country/Region as subject: America do norte Language: En Journal: Sleep Med Journal subject: NEUROLOGIA / PSICOFISIOLOGIA Year: 2020 Document type: Article Country of publication: