Porfimer sodium-mediated photodynamic therapy in patients with head and neck squamous cell carcinoma.
Photodiagnosis Photodyn Ther
; 29: 101627, 2020 Mar.
Article
in En
| MEDLINE
| ID: mdl-31866532
ABSTRACT
BACKGROUND:
Photodynamic therapy is a less invasive therapeutic procedure for carcinomas. The goal of this study was to evaluate the utility of Photofrin (porfimer sodium)-mediated photodynamic therapy in patients with head and neck squamous cell carcinoma.METHODS:
Forty-two head and neck squamous cell carcinoma patients who underwent Photofrin-mediated photodynamic therapy were treated by intraoperative light activation at 630â¯nm via a fiber optic microlens, 48â¯h after injection. We evaluated the impact of age, sex, tumor stage, primary site, light dose, and cancer history on overall survival using a Cox proportional hazards model. Information on the survival status of patients was obtained after a mean follow-up period of 51 months (range, 6-180 months).RESULTS:
The 5-year overall survival for all patients was 57.8 % (95 % confidence interval of the survival rate 39.8 %-72.1 %). The complete response rate was 69.0 %, and the efficacy (complete responseâ¯+â¯partial response) was 97.6 %. Earlier tumor stage was associated with increased survival (pâ¯=â¯0.012). Diseases of the respiratory tract also showed significant association with survival as compared to those of the alimentary tract (pâ¯=â¯0.01).CONCLUSIONS:
Photofrin-mediated photodynamic therapy is useful for treating head and neck squamous cell carcinomas, and provides an improved quality of life in patients with recurrent or residual disease.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Photochemotherapy
/
Dihematoporphyrin Ether
/
Squamous Cell Carcinoma of Head and Neck
/
Antineoplastic Agents
Type of study:
Prognostic_studies
Aspects:
Patient_preference
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Photodiagnosis Photodyn Ther
Journal subject:
DIAGNOSTICO POR IMAGEM
/
TERAPEUTICA
Year:
2020
Document type:
Article