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CGF Treatment of Leg Ulcers: a Randomized Controlled Trial.
Amato, Bruno; Farina, Michele Angelo; Campisi, Silvana; Ciliberti, Marino; Donna, Vincenzo Di; Florio, Anna; Grasso, Antonino; Miranda, Rosario; Pompeo, Francesco; Farina, Eleonora; Serra, Raffaele; Cirocchi, Roberto; Calemma, Francesca; Rocca, Aldo; Compagna, Rita.
Affiliation
  • Amato B; Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy.
  • Farina MA; Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Catanzaro, Italy.
  • Campisi S; Vascular Surgery Unit, Villa Del Sole Hospital 81100 Caserta, Italy.
  • Ciliberti M; Transfusion Immunohematology Service, S.Andrea Hospital, 00192 Rome, Italy.
  • Donna VD; Ulcer Service Program, Castellammare Di Stabia, Naples, Italy.
  • Florio A; Medical Center Regeneration Home, Corato, Foggia,Italy.
  • Grasso A; Department of Cardio-thoracic and Respiratory Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Miranda R; Vascular Surgery Unit, University of Catania, "Policlinico, Vittorio Emanuele" P.O. G. Rodolico , Catania, Italy.
  • Pompeo F; Angiology Service ASL NA 3 Sud, Nola District, 80035 Nola, Napoli, Italy.
  • Farina E; Vascular Surgery Unit, Neurologic Mediterranean Institute Neuromed, 86077 Pozzilli, Isernia, Italy.
  • Serra R; Vascular Surgery Unit, Villa Del Sole Hospital 81100 Caserta, Italy.
  • Cirocchi R; Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Catanzaro, Italy.
  • Calemma F; Department of Medical and Surgical Science, University Magna Graecia of Catanzaro, Catanzaro, Italy.
  • Rocca A; Department of Surgical and Biomedical Sciences, Division of Week surgery, S. Maria Hospital, Terni, Italy.
  • Compagna R; Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy.
Open Med (Wars) ; 14: 959-967, 2019.
Article in En | MEDLINE | ID: mdl-31934641
ABSTRACT

BACKGROUND:

Concentrated Growth Factors (CGF) is a concentration of second generation autologous growth factors compared to platelet rich plasma (PRP) and represents a multifactorial stimulation system that can be used for the management and treatment of chronic skin ulcers.

AIM:

The aim of this work is to evaluate the additional benefits of the CGF compared to the standard of dressing and its effects on the dynamics of the healing process.

METHODS:

Autologous CGFs were obtained from 100 patients with chronic mixed ulcers (venous ulcers in patients with II stage claudication) of the lower limbs in a multicentric controlled randomized study.

RESULTS:

The results showed a significant advantage in the use of CGF in association with cleansing and selective compression in the healing time and stabilization of mixed ulcers of the lower extremities.

CONCLUSIONS:

These results support the CGF's clinical use for improving clinical outcomes in mixed ulcers of the legs.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Clinical_trials Language: En Journal: Open Med (Wars) Year: 2019 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Clinical_trials Language: En Journal: Open Med (Wars) Year: 2019 Document type: Article Affiliation country: