Oestrogenic Endocrine Disruptors in the Placenta and the Fetus.
Int J Mol Sci
; 21(4)2020 Feb 23.
Article
in En
| MEDLINE
| ID: mdl-32102189
ABSTRACT
Endocrine disrupting chemicals (EDCs) are exogenous substances that interfere with the stability and regulation of the endocrine system of the body or its offspring. These substances are generally stable in chemical properties, not easy to be biodegraded, and can be enriched in organisms. In the past half century, EDCs have gradually entered the food chain, and these substances have been frequently found in maternal blood. Perinatal maternal hormone levels are unstable and vulnerable to EDCs. Some EDCs can affect embryonic development through the blood-fetal barrier and cause damage to the neuroendocrine system, liver function, and genital development. Some also effect cross-generational inheritance through epigenetic mechanisms. This article mainly elaborates the mechanism and detection methods of estrogenic endocrine disruptors, such as bisphenol A (BPA), organochlorine pesticides (OCPs), diethylstilbestrol (DES) and phthalates (PAEs), and their effects on placenta and fetal health in order to raise concerns about the proper use of products containing EDCs during pregnancy and provide a reference for human health.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pesticides
/
Placenta
/
Endocrine Disruptors
/
Fetus
Limits:
Animals
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Int J Mol Sci
Year:
2020
Document type:
Article
Affiliation country: