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Vascular endothelium-targeted Sirt7 gene therapy rejuvenates blood vessels and extends life span in a Hutchinson-Gilford progeria model.
Sun, Shimin; Qin, Weifeng; Tang, Xiaolong; Meng, Yuan; Hu, Wenjing; Zhang, Shuju; Qian, Minxian; Liu, Zuojun; Cao, Xinyue; Pang, Qiuxiang; Zhao, Bosheng; Wang, Zimei; Zhou, Zhongjun; Liu, Baohua.
Affiliation
  • Sun S; Anti-aging & Regenerative Medicine Research Institution, School of Life Sciences, Shandong University of Technology, Zibo 255049, China.
  • Qin W; National Engineering Research Center for Biotechnology (Shenzhen), Carson International Cancer Center, Medical Research Center, Shenzhen University Health Science Center, Shenzhen, China.
  • Tang X; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Shenzhen University Health Science Center, Shenzhen, China.
  • Meng Y; National Engineering Research Center for Biotechnology (Shenzhen), Carson International Cancer Center, Medical Research Center, Shenzhen University Health Science Center, Shenzhen, China.
  • Hu W; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Shenzhen University Health Science Center, Shenzhen, China.
  • Zhang S; National Engineering Research Center for Biotechnology (Shenzhen), Carson International Cancer Center, Medical Research Center, Shenzhen University Health Science Center, Shenzhen, China.
  • Qian M; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Shenzhen University Health Science Center, Shenzhen, China.
  • Liu Z; National Engineering Research Center for Biotechnology (Shenzhen), Carson International Cancer Center, Medical Research Center, Shenzhen University Health Science Center, Shenzhen, China.
  • Cao X; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Shenzhen University Health Science Center, Shenzhen, China.
  • Pang Q; National Engineering Research Center for Biotechnology (Shenzhen), Carson International Cancer Center, Medical Research Center, Shenzhen University Health Science Center, Shenzhen, China.
  • Zhao B; National Engineering Research Center for Biotechnology (Shenzhen), Carson International Cancer Center, Medical Research Center, Shenzhen University Health Science Center, Shenzhen, China.
  • Wang Z; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Shenzhen University Health Science Center, Shenzhen, China.
  • Zhou Z; National Engineering Research Center for Biotechnology (Shenzhen), Carson International Cancer Center, Medical Research Center, Shenzhen University Health Science Center, Shenzhen, China.
  • Liu B; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Shenzhen University Health Science Center, Shenzhen, China.
Sci Adv ; 6(8): eaay5556, 2020 02.
Article in En | MEDLINE | ID: mdl-32128409
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Progeria / Endothelium, Vascular / Genetic Therapy / Sirtuins / Longevity Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Sci Adv Year: 2020 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Progeria / Endothelium, Vascular / Genetic Therapy / Sirtuins / Longevity Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Sci Adv Year: 2020 Document type: Article Affiliation country: Country of publication: