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Complexities in Genetics of Psoriatic Arthritis.
Rahmati, Sara; Tsoi, Lam; O'Rielly, Darren; Chandran, Vinod; Rahman, Proton.
Affiliation
  • Rahmati S; Department of Medicine, Faculty of Medicine, Memorial University, St. John's, Newfoundland and Labrador, A1B 3X9, Canada.
  • Tsoi L; Krembil Research Institute, University Health Network, Toronto, Ontario, M5S 1A8, Canada.
  • O'Rielly D; Department of Computational Medicine & Bioinformatics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA.
  • Chandran V; Department of Medicine, Faculty of Medicine, Memorial University, St. John's, Newfoundland and Labrador, A1B 3X9, Canada.
  • Rahman P; Department of Medicine, Faculty of Medicine, Memorial University, St. John's, Newfoundland and Labrador, A1B 3X9, Canada.
Curr Rheumatol Rep ; 22(4): 10, 2020 03 12.
Article in En | MEDLINE | ID: mdl-32166449
ABSTRACT
PURPOSE OF THE REVIEW To provide a general overview and current challenges regarding the genetics of psoriatic disease. With the use of integrative medicine, multiple candidate loci identified to date in psoriatic disease will be annotated, summarized, and visualized. Recent studies reporting differences in genetic architecture between psoriatic arthritis and cutaneous-only psoriasis will be highlighted. RECENT

FINDINGS:

Focusing on functional pathways that connect previously identified genetic variants can increase our understanding of psoriatic diseases. The genetic architecture differs between psoriatic arthritis and cutaneous-only psoriasis with arthritis-specific signals in linkage disequilibrium independent of the published psoriasis signals. Integrative medicine is helpful in understanding cellular mechanisms of psoriatic diseases. Careful selection of the psoriatic disease cohort has translated into mechanistic differences among psoriatic arthritis and cutaneous psoriasis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Psoriatic Type of study: Prognostic_studies Limits: Humans Language: En Journal: Curr Rheumatol Rep Journal subject: REUMATOLOGIA Year: 2020 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Psoriatic Type of study: Prognostic_studies Limits: Humans Language: En Journal: Curr Rheumatol Rep Journal subject: REUMATOLOGIA Year: 2020 Document type: Article Affiliation country: