Embrittlement of collagen in early-stage human osteoarthritis.
J Mech Behav Biomed Mater
; 104: 103663, 2020 04.
Article
in En
| MEDLINE
| ID: mdl-32174421
ABSTRACT
Articular cartilage is a remarkable material with mechanical performance that surpasses engineering standards. Collagen, the most abundant protein in cartilage, plays an important role in this performance, and also in disease. Building on observations of network-level collagen changes at the earliest stages of osteoarthritis, this study explores the physical role of the collagen fibril in the disease process. Specifically, we focus on the material properties of collagen fibrils in the cartilage surface. Ten human tibial plateaus were characterised by atomic force microscopy (AFM) and Raman spectroscopy, with histological scoring used to define disease state. Measures of tropocollagen remained stable with disease progression, yet a marked mechanical change was observed. A slight stiffening coupled with a substantial decrease in loss tangent suggests a physical embrittlement caused by increased inter-molecular interactions.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteoarthritis
/
Cartilage, Articular
Limits:
Humans
Language:
En
Journal:
J Mech Behav Biomed Mater
Journal subject:
ENGENHARIA BIOMEDICA
Year:
2020
Document type:
Article
Affiliation country: